Tesamorelin

Tesamorelin Overview

Tesamorelin is a stabilized analogue of growth hormone-releasing hormone designed for research involving upstream endocrine signaling. In laboratory settings, it is used to examine how GHRH receptor activity influences pituitary signaling, growth hormone pathway dynamics, and broader hormone-regulated cellular processes.

Mechanism of Action & Applications

Tesamorelin is studied for agonist activity at the growth hormone-releasing hormone receptor. In research models, this makes it useful for examining pituitary receptor signaling, pulsatile growth hormone pathway activity, hypothalamic-pituitary axis biology, and broader endocrine communication systems. It is commonly used in studies involving GHRH receptor pharmacology, peptide stability, endocrine signaling, and growth hormone pathway regulation.

Research History

Tesamorelin developed from earlier work on native GHRH and shorter GHRH analogues designed to improve stability and preserve receptor activity. As research expanded, tesamorelin became a useful peptide for studying how structural modification can affect peptide half-life, receptor engagement, and downstream endocrine signaling behavior.

Chemical Information

CAS Number: 218949-48-5
Molecular Formula: C₂₂₁H₃₆₆N₇₂O₆₇S
Molecular Weight: 5135.9 g/mol
PubChem ID: 16137834
Purity: ≥99%