GLP-2 TZ

GLP-2 TZ Overview

GLP-2 TZ is a dual-receptor peptide studied for activity across GIP and GLP-1 pathways. In research settings, it is used to examine how these two receptor systems work together and how combined receptor activity influences broader metabolic and endocrine signaling. Tirzepatide has been described in the literature as an acylated peptide engineered to activate both the GIP and GLP-1 receptors.

Mechanism of Action & Applications

GLP-2 TZ is studied as a dual agonist at the GIP and GLP-1 receptors. This receptor profile allows researchers to examine how simultaneous activation of incretin-related pathways affects intracellular signaling, hormone pathway coordination, and broader metabolic system responses. Published mechanistic work also describes tirzepatide as having stronger relative activity at the GIP receptor and biased signaling behavior at the GLP-1 receptor, which makes it a useful compound for studying receptor-selective signaling and dual-incretin pathway biology. It is commonly used in research involving incretin receptor biology, metabolic signaling, endocrine regulation, and multi-pathway peptide signaling.

Research History

GLP-2 TZ builds on earlier incretin research that first focused on GLP-1 receptor agonists and later expanded into compounds designed to engage both GIP and GLP-1 receptors. This progression led to dual-agonist peptides like GLP-2 TZ, which are studied for more integrated pathway research involving incretin signaling and metabolic system coordination.

Chemical Information

CAS Number: 2023788-19-2
Molecular Formula: C₂₂₅H₃₄₈N₄₈O₆₈
Molecular Weight: 4813.45 g/mol
PubChem ID: 166567236
Purity: ≥99%