GHK-Cu

GHK-Cu Overview

GHK-Cu is a naturally occurring copper peptide complex formed by the tripeptide glycyl-L-histidyl-L-lysine bound to copper(II). In research settings, it is studied for its role in copper transport, peptide-mediated signaling, and broader cellular processes related to tissue biology, gene expression, and extracellular matrix regulation.

Mechanism of Action & Applications

GHK-Cu is studied for how it binds and transports copper ions and how that interaction influences downstream cellular signaling. In laboratory research, this makes it useful for examining copper-dependent enzyme systems, extracellular matrix biology, antioxidant pathway activity, and peptide signaling related to cellular maintenance and structural pathway regulation.

Research History

GHK was first identified in human plasma and later became a subject of interest after researchers observed its strong affinity for copper and its broad activity in cell and tissue models. Over time, GHK-Cu became widely studied in research involving peptide-copper complexes, cellular signaling, and matrix-related biological systems.

Chemical Information

CAS Number: 89030-95-5
Molecular Formula: C₁₄H₂₄CuN₆O₄
Molecular Weight: 403.93 g/mol
PubChem ID: 16219740
Purity: ≥99%