Cagrilintide

Cagrilintide Overview

Cagrilintide is a long-acting peptide analogue of amylin studied in metabolic research. In laboratory and clinical research settings, it is used to examine amylin-related signaling and how this pathway interacts with broader metabolic regulation systems.

Mechanism of Action & Applications

Cagrilintide is studied for agonist activity at amylin and calcitonin-family receptor systems. Research has examined how this receptor activity influences downstream signaling involved in metabolic regulation, making it useful in studies of amylin biology, receptor pharmacology, and multi-pathway metabolic signaling. More recent structural work has also described how cagrilintide engages these receptors through an amylin-like binding mode while producing distinct receptor conformations and dynamics.

Research History

Cagrilintide emerged from efforts to develop a longer-acting amylin analogue with improved stability and sustained receptor activity. Published medicinal chemistry work in 2021 described its development as a stable, lipidated long-acting amylin analogue, and later studies further characterized its receptor activity and structural behavior.

Chemical Information

CAS Number: 1415456-99-3
Molecular Formula: C₁₉₄H₃₁₂N₅₄O₅₉S₂
Molecular Weight: 4409 g/mol
PubChem ID: 167312356
Purity: ≥99%