ARA-290

ARA-290 Overview

ARA-290, also known as cibinetide, is an 11-amino-acid peptide derived from the helix B surface of erythropoietin. In research settings, it is studied for selective activity at tissue-protective receptor systems rather than classical erythropoietic signaling, making it a useful compound for examining repair-associated and stress-response pathways at the cellular level.

Mechanism of Action & Applications

ARA-290 is studied for selective signaling at the non-hematopoietic erythropoietin receptor complex, often described as a receptor system involving EPOR and the beta common receptor (CD131). In laboratory research, this makes it useful for examining tissue-protective signaling, inflammatory pathway modulation, cellular stress responses, and receptor activity linked to non-erythropoietic erythropoietin biology. It is commonly used in studies involving inflammatory signaling, neuropathic pathway models, metabolic stress biology, and broader cell-protection research.

Research History

ARA-290 emerged from efforts to isolate the tissue-protective properties of erythropoietin without reproducing its red blood cell stimulating effects. This led to the development of smaller erythropoietin-derived peptides such as cibinetide, which were then studied in preclinical and clinical research models involving inflammatory, metabolic, and neurologic pathway activity.

Chemical Information

CAS Number: 1208243-50-8
Molecular Formula: C₅₁H₈₄N₁₆O₂₁
Molecular Weight: 1257.31 g/mol
PubChem ID: 91810664
Purity: ≥99%