5-Amino-1MQ

5-Amino-1MQ Overview

5-Amino-1MQ is a quinolinium-based small molecule studied in metabolic research involving NNMT, an enzyme that uses nicotinamide as a substrate in methylation-related biochemical processes. In laboratory settings, it is used to examine how NNMT activity affects cellular energy metabolism, NAD+-linked biology, and broader metabolic signaling.

Mechanism of Action & Applications

5-Amino-1MQ is studied as an NNMT inhibitor. In research models, this makes it useful for examining how reduced NNMT activity changes intracellular nicotinamide handling, methyl donor utilization, and downstream metabolic signaling. It is commonly used in studies involving cellular metabolism, NAD+-associated pathways, adipocyte biology, and enzyme-driven metabolic regulation.

Research History

Research interest in 5-Amino-1MQ grew from broader efforts to understand NNMT as a regulator of metabolic and epigenetic biology. Published work has described 5-Amino-1MQ as a selective, cell-permeable small-molecule NNMT inhibitor and has used it in controlled models to study enzyme inhibition, metabolic pathway changes, and related cellular responses.

Chemical Information

CAS Number: 42464-96-0
Chemical Name: 5-Amino-1-methylquinolinium iodide
Molecular Formula: C₁₀H₁₁IN₂
Molecular Weight: 286.11 g/mol
Purity: ≥99%