Sermorelin

Sermorelin Overview

Sermorelin is a 29-amino-acid analogue of growth hormone-releasing hormone and is widely described as the shortest synthetic fragment that retains the full biologic activity of native GHRH. In research settings, it is used to examine GHRH receptor signaling and how upstream hypothalamic peptide activity influences downstream growth hormone pathway function.

Mechanism of Action & Applications

Sermorelin is studied for agonist activity at the growth hormone-releasing hormone receptor. In laboratory research, this makes it useful for examining pituitary signaling, pulsatile growth hormone release dynamics, receptor activation patterns, and broader endocrine pathway regulation linked to the hypothalamic-pituitary-somatotropic axis.

Research History

Research on sermorelin developed from earlier work on GHRH analogues designed to preserve biologic activity while using a shorter, more defined peptide fragment. Published reviews and earlier comparative studies describe sermorelin as a well-established GHRH analogue used in both endocrine and receptor-signaling research.

Chemical Information

CAS Number: 86168-78-7
Molecular Formula: C₁₄₉H₂₄₆N₄₄O₄₂S
Molecular Weight: 3357.9 g/mol
PubChem ID: 16132413
Purity: ≥99%