Ipamorelin

Ipamorelin Overview

Ipamorelin is a pentapeptide originally developed within the growth hormone secretagogue class and is commonly described as a selective ghrelin receptor agonist. In research settings, it is used to examine receptor-mediated endocrine signaling and how ghrelin-pathway activation influences pituitary and metabolic system activity.

Mechanism of Action & Applications

Ipamorelin is studied for agonist activity at the growth hormone secretagogue receptor, also known as the ghrelin receptor or GHSR1a. In laboratory research, this makes it useful for examining receptor activation, intracellular signaling, pituitary hormone pathway dynamics, and broader ghrelin-related endocrine biology. It is commonly used in studies involving ghrelin receptor pharmacology, growth hormone secretagogue signaling, peptide-receptor selectivity, and neuroendocrine pathway research.

Research History

Ipamorelin emerged from medicinal chemistry efforts to develop growth hormone secretagogues with a more selective signaling profile. A 1998 paper described it as the first selective growth hormone secretagogue and identified its pentapeptide sequence as Aib-His-D-2-Nal-D-Phe-Lys-NH2, which helped distinguish it from earlier compounds in the same class.

Chemical Information

CAS Number: 170851-70-4
Molecular Formula: C₃₈H₄₉N₉O₅
Molecular Weight: 711.9 g/mol
PubChem ID: 9831659
Purity: ≥99%